The contribution of Fcgr4 macrophages to metabolic inflammation resolution
We previously found that weight loss in obesity promotes the accumulation of a novel macrophage subtype in the visceral adipose tissue, and that these cells disappear with weight regain. This project aims at understanding the function, origin and fate of these novel macrophages and their contribution to healing of obesity-related diseases.
The effects of weight loss and regain on immune progenitors
Progenitor cell responses are tightly regulated by metabolic processes and nutrient availability, both of which change dramatically in weight loss and regain. Changes occurring at the progenitor level affect inflammation in many tissues at the same time. We found that both weight loss and weight regain reprogram immune progenitors long-term. This project aims at determining how weight fluctuations influence immune progenitors to promote healing immunity in weight loss and heightened inflammation in weight regain.
The effects of weight loss and regain on female fertility
Obesity is associated with several fertility issues in both men and women, including difficulties in getting pregnant and increased rates of miscarriages and difficult (assisted) deliveries. We found that this is even further exacerbated by fluctuations in body weight. This project aims to identify the cellular and molecular mechanisms responsible for these fertility abnormalities in females undergoing weight cycling.
We previously found that weight loss in obesity promotes the accumulation of a novel macrophage subtype in the visceral adipose tissue, and that these cells disappear with weight regain. This project aims at understanding the function, origin and fate of these novel macrophages and their contribution to healing of obesity-related diseases.
The effects of weight loss and regain on immune progenitors
Progenitor cell responses are tightly regulated by metabolic processes and nutrient availability, both of which change dramatically in weight loss and regain. Changes occurring at the progenitor level affect inflammation in many tissues at the same time. We found that both weight loss and weight regain reprogram immune progenitors long-term. This project aims at determining how weight fluctuations influence immune progenitors to promote healing immunity in weight loss and heightened inflammation in weight regain.
The effects of weight loss and regain on female fertility
Obesity is associated with several fertility issues in both men and women, including difficulties in getting pregnant and increased rates of miscarriages and difficult (assisted) deliveries. We found that this is even further exacerbated by fluctuations in body weight. This project aims to identify the cellular and molecular mechanisms responsible for these fertility abnormalities in females undergoing weight cycling.