Obesity is a major health challenge that is associated with a heightened immune response, resulting in many diseases, including heart disease, allergy and even cancer. One intervention that greatly improves and heals obesity-related inflammation is weight loss, while weight fluctuation (weight loss and regain cycles) enhances these harmful immune responses. 
We aim to learn from success and understand how weight loss influences immunity to heal metabolic inflammation. Since weight loss is so challenging, we aim to leverage these findings to treat obesity-related diseases without the need for weight loss. 
Another interest of our group is to understand why weight cycling enhances inflammation. This will allow us to find treatments to retain the benefits of weight loss, even if individuals regain weight.
Our overarching goal is to heal metabolic inflammation independently of weight loss and prevent the harmful effects of weight regain.